![]() ![]() In vitro enzyme assays demonstrate that all seven BTPSL genes from the genus Metarhizium encode active enzymes with sesquiterpene synthase activities of two general product profiles. ![]() These include a monophyletic clade of nine fungal TPS genes, designated as BTPSL for bacterial TPS-like genes, from eight species of related entomopathogenic fungi, including seven TPSs from six species in the genus Metarhizium. Nested in the bacterial TPS clade is a number of fungal TPS genes that are inferred as the outcome of HGT. Phylogenetic analysis placed the majority of fungal and bacterial TPS genes from diverse taxa into two clades, indicating ancient divergence. ![]() Here we report that fungi have acquired terpene synthase genes ( TPSs), which encode pivotal enzymes for terpenoid biosynthesis, from bacteria through HGT. However, it remains unclear whether HGT has played a role in creating the enormous chemical diversity of fungal terpenoids. Horizontal gene transfer (HGT) is an important mechanism contributing to genetic innovation of fungi. They are known as rich producers of secondary metabolites, especially terpenoids, which are important for fungi-environment interactions. Fungi are successful eukaryotes of wide distribution. ![]()
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